The extracellular matrix (ECM) that gives tissue its structural integrity is remodelled in skin aging/photoaging and cancer via the increased expression/activites of matrix metalloproteinases (MMP), inhibition of the tissue inhibitors of matrix metalloproteinases (TIMP), or inhibition of collagen synthesis. Transforming growth factor-β (TGF-β), a predominant regulator of the ECM, is inhibited in aging/photoaging and stimulated in carcinogenesis. P. leucotomos extract has potential to counteract these alterations via its antioxidant, anti-inflammatory and photoprotective properties.
The intake or topical application of P.leucotomos may be beneficial to skin health, in aging and cancer prevention or treatment.


Polypodium leucotomos demonstrated dual protective effects on the extracellular matrix for anti-aging skin via the inhibition of the extracellular matrix proteolytic enzymes and the stimulation of collagen, and transforming growth factor-β in fibroblast (cells responsible to stimulation of collagen, elastin and hyaluronic acid). Its topical or oral administration is tolerated without toxicity for protection against UV radiation, depletion of Langerhans cells, erytherma (redness) and skin damage.