Exposure of human skin to sunlight containing UV radiation A and B, leads to deleterious effects on skin such as sunburn, immune suppression, pigmentary changes, photoaging , and skin cancer. Protection of skin by an oral photoprotective agent would have substantial benefits. A total of 9 healthy participants were exposed to varying doses of artificial UV radiation without and after oral administration of Polypodium leucotomos (PL). At 24 hours after exposure the redness was assessed from Polypodium leucotomos treated and untreated skin.



A significant decrease in redness was found in Polypodium leucotomos treated skin. Histologically, in Polypodium leucotomos treated biopsy specimens showed less sunburn cells. In conclusion, oral PL is an effective systemic agent as it leads to a significant decrease of UV-induced redness, sunburn cell formation, DNA damage, etc. These short-term results are promising as they suggest that PL might be able to protect against long-tern UV-induced skin damage.