The effect of overexposure to ultraviolet radiation in the development of skin diseases and melanoma has been clearly demonstrated in recent years, and thus the need for developing protective reagents is an active field of study. Protection should prevent the development of serve burns. Hyperpigmentation, photoallergy and phototoxicity, skin cancer and chronic skin damage, and premature aging. Thus the effect of a fern Polypodium leucotomos has been investigated in terms of photoprotection against UV-induced cell damage.


In this study, Polypodium leucotomos presents a dual profile in the treatment of skin lesions, protecting the tissue from UV-induced damage and limiting the extent of the inflammatory response upon damage, making it a promising candidate in the treatment of UV-damage related skin diseases that cause a depletion of Langerhans cells, whichhas been related to tumor necrosis factor accumulation.
Furthermore, it was displayed that Polypodium leucotomos has the best antioxidant properties as compared to vitamin C, E and A. The cell survival rates in Polypodium leucotmos is the highest, ensuring the abilities of it quenching reactive oxygen species (free radicals).
*Langerhans cells – cells in the skin that activate white blood cells. It plays a major role in skin’s immune responses.